2024 Stat6 molecular weight

Stat6 molecular weight

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August undefined, 2024

WebDec 10, 2024 · Author summary STAT6 is a transcriptional factor that plays an important role in the extracellular cytokine and virus-mediated immune response. Extensive studies have revealed that the dysregulation of STAT6 is linked to the pathological features of virus-associated cancers. However, the molecular mechanism of STAT6 regulation by tumor … WebSTAT6 fusion protein Ag0410: Full Name: signal transducer and activator of transcription 6, interleukin-4 induced: Calculated molecular weight: 100 kDa: Observed molecular weight: 95 kDa: GenBank accession number: BC005823: Gene symbol: STAT6: Gene ID (NCBI) 6778: Conjugate: Unconjugated: Form: Liquid: Purification Method: Protein A ...

Recombinant Human STAT6 GST (N-Term) Protein - Novus Biologi…

WebThe calculated molecular weight of CHO cell-derived Recombinant Human sFRP-4 is 37.8 kDa; however, due to glycosylation, the protein migrates at an apparent molecular weight of approximately 55 - 65 kDa by SDS-PAGE analysis under reducing conditions. ... 重组人STAT6蛋白 ... WebMA5-15659 detects STAT6 which has a predicted molecular weight of approximately 94kDa. Target Information STAT6 protein is a transcription factor activated by cytokines, … david melech lyrics

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WebSTAT6, also named as Signal transducer and activator of transcription 6, is a 847 amino acid protein, which belongs to the transcription factor STAT family. STAT6 forms a homodimer … WebSTAT6 (predicted molecular weight 94kDa) has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the ... WebStat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in … david meister white dresses

STAT6 Monoclonal Antibody (7D3) (MA5-15659) - Thermo Fisher …

STAT6 protein expression summary - The Human Protein …

WebOct 14, 2011 · We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser (407) by TBK1 and Tyr (641), independent of JAKs. … WebSTAT6 (predicted molecular weight 94kDa) has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the ... gas station mod lspdfr david melius new orleans

"WebNumbers on the left refer to molecular weight standards. B, stabilization of dimeric STAT6. Proteins were expressed in HEG293 cells, and nuclear extracts prepared from IL-4-treated cells were subjected to DNA binding. " - Stat6 molecular weight

Stat6 molecular weight

STAT6 Protein - an overview ScienceDirect Topics

WebMolecular Weight of Stat6: 119 kDa. Positive Controls: NIH/3T3 whole cell lysate: sc-2210, KNRK whole cell lysate: sc-2214 or BJAB whole cell lysate: sc-2207. DATA SELECT PRODUCT CITATIONS 1. Majka, M., et al. 2000. Stromal-derived factor 1 … WebApr 12, 2024 · Lackmann and colleagues probed the molecular size distribution of several STAT proteins in detergent-free HeLa cell extracts and found that they resided in cytoplasmic high-molecular weight complexes prior to any cytokine action, except for STAT6, which fractionated according to its monomeric molecular weight, consistent with …

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WebThe MA5-15659 immunogen is purified recombinant fragment of human STAT6 expressed in E. Coli. MA5-15659 detects STAT6 which has a predicted molecular weight of approximately 94kDa. Target Information STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. WebMay 8, 2024 · Macromolecule Content Total Structure Weight: 18.26 kDa Atom Count: 884 Modelled Residue Count: 118 Deposited Residue Count: 164 Unique protein chains: 2 Display Files Download Files 5NWX Insight …

WebJul 1, 1998 · The STAT family is comprised of 6 members, STAT1–STAT6, with molecular weights ranging from 84–113 kDa; their main function is to serve as transactivators of cytokine specific genes [1]. Recently, an ∼100 kDa catfish STAT homolog was identified by screening a variety of commercially available antibodies to mammalian STAT6 [3]. WebImmunogen: Phosphorylated Human Stat6 (pY641) Application: Intracellular staining (flow cytometry) (Routinely Tested) Target Molecular Weight: 100 kDa Vol. Per Test: 20 µl RRID: …

WebWilliam E. Paul, in Encyclopedia of Hormones, 2003 IV IL-4 receptor signaling mechanisms. Addition of IL-4 to resting T cells leads to rapid phosphorylation of Stat6; each of the three … WebJan 13, 2013 · SFT-14 tumor expresses the larger 150-kDa NAB2-STAT6 fusion protein. SFT-10 and SFT-44 tumors both express the smaller, more common 90-kDa NAB2-STAT6 …

WebSTAT6 −/− mice have increased lethality, inflammation, and cytokine production in a noninfection induced model of endotoxemia, but reduced lethality and enhanced …

WebMay 1, 2024 · Part of the Methods in Molecular Biology book series (MIMB,volume 1966) Abstract Activation of signal transducer and activator of transcription 6 (STAT6) is a key signaling pathway in macrophage function, and is required for the so-called alternative (M2) activation of macrophages. david melillo knights of the island counterWebSTAT6 is the only STAT protein that prefers binding to DNA motifs with a N4 spacer. One STAT6 homodimer binds a palindromic DNA motif. Each monomer binds half of the … david mellor croweWebSignal Transducer and Activator of Transcription 6 (STAT6) is a member of the Janus family tyrosine kinases (Jak)/ STAT signal transduction pathway and mediates cytokine … gas station mobile payWebSTAT6 is tyrosine phosphorylated (Tyr641) in response to cellular interaction with IL-4. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 and Th9 immune response (2). david melchiorre law officeWebApr 15, 2024 · Molecular modeling suggested that the transfer of the ... As expected, none of the cytokines induced STAT6 phosphorylation. ... and weighed to calculate liver weight to body weight ratio and ... david mellor classic fm upcoming showsWebSTAT6 is mainly activated by cytokines interleukin-4 and interleukin-13. [5] Molecular biology [ edit] In the human genome, STAT6 protein is encoded by the STAT6 gene, … gas station mod minecraftWebAug 26, 2024 · As a matter of fact, the final model simulation by Takahashi et al. (2024) suggested the following doses according to metabolizer status and weight to achieve target trough concentrations of 1.5–5.0 mg/L: for normal metabolizers: 16 mg/kg (15 kg weight), 12 mg/kg (15–30 kg weight), or 10 mg/kg (30 kg weight); doses were 33–50% lower for ... david mellinkoff the language of the law pdf