Stat3 nuclear translocation
WebApr 11, 2024 · nuclear translocationの意味について. 「 nuclear translocation 」は2つの英単語（ nuclear、translocation ）が組み合わさり、1つの単語になっている英単語です … WebOct 25, 2024 · STAT3 is an 89 kDa protein encoded by the STAT3 gene. It is 770 amino acids in length and is composed of six functional domains. The NH 2 -terminal domain participates in higher order complex formation. This is followed by the coiled-coil domain involved in protein-protein interactions with co-regulators and transcription factors.
Stat3 nuclear translocation
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WebApr 13, 2024 · To identify more specific downstream mediators of IL-6 signaling, we next used the selective STAT3 inhibitor STATTIC. This small molecule inhibitor inhibits activation, dimerization, and nuclear translocation of STAT3 . We first optimized the concentration of STATTIC to avoid apoptosis in the Hep3B cells using Puromycin-treated cells as ... WebTo verify the functional implication of STAT3 phosphorylation in HDMEC migration, we introduced a dominant-negative STAT3 using adenovirus vector system. Dominant …
WebJun 8, 2009 · The major mechanism of STAT3 activation in tumor cells is mediated through the phosphorylation of STAT3 on tyrosine residue 705, leading to its dimerization … WebMay 26, 2005 · STAT3 can act as an oncogene, and its function has been shown to be critical for cellular transformation by a number of oncogenic tyrosine kinases. The role of …
WebApr 18, 2024 · STAT3 cytoplasmic transcription factor exists as a stable and unphosphorylated dimer shuttling between cytoplasm and nucleus in the absence of activators. In response to extracellular signaling protein molecules like cytokines and growth factors, STAT3 mediates targeted gene expression. WebNov 1, 2009 · On exposure to EGF, we observed STAT3 phosphorylation and rapid formation of the PIAS3-STAT3 complex. Within 5 minutes, there was a progressive translocation of the complex to the nucleus, and by 10 minutes, PIAS3 was uniquely localized to the nuclear compartment. After 30 minutes, PIAS3 returned to the cytoplasm.
To confirm whether N4 was influenced by STAT3 activation in pancreatic cancer cells. PANC-1, CAPAN-2, and BXPC-3 cells were treated with the indicated concentrations of N4. After 24 h, the cells were then lysed for western blot analysis. N4 selectively blocked STAT3 Tyr705 phosphorylation but … See more To identify compounds capable of inhibiting the STAT3 SH2 domain, we configured a STAT3-specific FP assay. The use of FP assay for STAT3-SH2 drug … See more Our data demonstrated that N4 was a potential STAT3 inhibitor and it inhibited STAT3 activation in pancreatic cancer. Then, we performed the docking assays … See more To further verify the antitumor effects of N4 in pancreatic cancer, the antitumor proliferation activities of N4 were examined. N4 effectively inhibited the proliferation … See more To test the antitumor effect of N4 in vivo, subcutaneous tumor growth xenograft models using PANC-1 was established. When the tumor volume reached 150 to … See more
WebResults: This study identified that inhibition of FTO in N43/5 cells led to phosphorylation of signal transducer and activator of transcription 3 (STAT3) at S727 site and induced p-STAT3-S727 nuclear translocation. We further showed that FTO inhibition promoted phosphorylation of ERK1/2; specific inhibition of ERK1/2 signaling by U0126 could ... order of service template for funeralWebJun 26, 2009 · Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor responsive to cytokine signaling and tyrosine kinase oncoproteins by nuclear translocation when it is tyrosine-phosphorylated. order of service sampleWebApr 25, 2024 · Stat3 was first identified in 1996 by researchers at Rockefeller University in the intracellular transduction of epidermal growth factor (EGF) and interleukin 6 (IL-6), and is commonly believed to be an acute response factor mediating growth factors and inflammatory factors ( Zhong et al., 1994 ). how to treat alternariaWebNuclear Translocation of Phosphorylated STAT3 Is Essential for Vascular Endothelial Growth Factor-induced Human Dermal Microvascular Endothelial Cell Migration and Tube Formation* Received for publication, February 21, 2003, and in revised form, June 20, 2003 Published, JBC Papers in Press, July 21, 2003, DOI 10.1074/jbc.M301866200 how to treat alzheimer\u0027sWebOct 10, 2003 · To verify the functional implication of STAT3 phosphorylation in HDMEC migration, we introduced a dominant-negative STAT3 using adenovirus vector system. … how to treat altitude sickness bsaWebJun 6, 2009 · Mitochondrial STAT3 sustained altered glycolytic and oxidative phosphorylation activities characteristic of cancer cells. Thus, in addition to its nuclear transcriptional role, STAT3 regulates a metabolic function in mitochondria, supporting Ras-dependent malignant transformation. order of services for churchorder of services for weddings