WebDec 22, 2024 · Rottlerin is a natural polyphenolic compound that was initially ... Psoriasis is a chronic inflammatory cutaneous disorder with undefined etiology and is characterized by abnormal cellular proliferation, angiogenesis, and ... However, the deep mechanism still requires further study. Publication types ... WebJan 4, 2012 · Rottlerin exhibits a number of therapeutic effects against a variety of cancer cells. Because of the differences in Rottlerin outcomes, cellular models, experimental strategies, and exploited pathways, the current status of the Rottlerin anticancer potential against various cancers is analyzed below under different headings.
Rottlerin as a therapeutic approach in psoriasis: Evidence from in ...
WebFeb 27, 2013 · Rottlerin, a novel macropinocytosis inhibitor which is rapid acting, irreversible, and selective, was discovered in 2005. ... Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes … WebDec 20, 2012 · For example, Rottlerin sensitizes cancer cells to apoptotic stimuli [7–9] and promotes autophagy in certain cell types [10–12]. Rottlerin, however, possesses so many biological activities that the primary molecular target and mechanism of action by which Rottlerin can kill cancer cells are unpredictable [13, 14]. earthship plans scribd
Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells
WebThe biophysical mechanism underlying the effect of rottlerin has not been fully investigated but the rottlerin effect does not depend on intact Ca 2 ... Uptake of Flock House virus by … WebAug 1, 2003 · The results suggest a novel mechanism for regulation of the GLAST subtype of glutamate transporter and indicate that there is a rottlerin target that is capable of controlling the levels of GLAST by controlling the rate of degradation or limited proteolysis. Protein kinase C (PKC) regulates the activity and/or cell surface expression of several … WebJan 4, 2012 · Rottlerin exhibits a number of therapeutic effects against a variety of cancer cells. Because of the differences in Rottlerin outcomes, cellular models, experimental … ctown unionport