Webb15 dec. 2024 · Using murine allo-HSCT models, we show that pharmacologic Janus kinase 1/2 (JAK1/2) inhibition combined with CD45- or cKit-targeted ADCs enables robust multilineage alloengraftment. Strikingly, myeloid lineage donor chimerism exceeding 99% was achievable in fully MHC-mismatched HSCT using this approach. Webb14 dec. 2024 · We used a fully MHC-mismatched (BALB/c (H-2k d) → C57BL/6 (H-2 kb) murine models (Fig. 3a). There were no differences in weight loss among the groups, while the animals treated with the combination had lower clinical scores than the control and MSC- or Treg-alone treated animals (Fig. 3 b).
MHC restriction — why do T cells only target some infected cells?
Webb28 juni 2024 · We conclude from our biochemical and in silico analyses of peptide-HLA-binding that rigid and high-affinity binding of peptides is one of the most important … Webb4 feb. 2024 · Allogeneic mesenchymal stem cells (MSCs) are a promising cell therapy for treating numerous diseases, but major histocompatibility complex (MHC)-mismatched MSCs can be rejected by the recipient’s immune system. Pre-treating MSCs with transforming growth factor-β2 (TGF-β2) to downregulate surface expression of MHC … cannock sweet shop
Competency of iPSC-derived retinas in MHC-mismatched …
WebbAbstract. Background: Allogeneic mesenchymal stem cells (MSCs) are a promising cell source for treating musculoskeletal injuries in horses. Controversy exists, however, over … WebbAlthough MHC-homo-iPSCs are preferred to avoid immune rejection, MHC-mismatched iPSC-CMs can also induce comparable cardiac functional recovery at late follow-up, … Webb25 maj 2024 · In this study, we employed two syngeneic murine tumor models expressing distinct model antigens presented in the context of the MHC-I molecule, H-2K b (K b), to determine the extent to which MHC-I cross-dressing was involved in antigen-specific CD8 + T cell priming. Although the magnitude of the effect varied, CD8 + T cell priming … cannock swimming pool