Web1 dec. 2003 · Megalin was first identified by Kerjaschki and Farquhar and later found to be a member of the low-density lipoprotein receptor family, composed of a single-transmembrane domain, a large ectodomain, and a short cytoplasmic tail (10–12).Megalin mediates tubular uptake of low-molecular-weight proteins in the kidney and is also involved in the … LRP2/megalin functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2/megalin can also form complexes with CUBAM , the cubilin and amnionless complex. Those complexes are able to reabsorb several molecules and can be inhibited by sodium maleate. Meer weergeven Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene. Meer weergeven LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of … Meer weergeven LRP2 has been shown to associate with the following proteins in the plasma membrane/cytosol of cells: • CUBAM, • DAB2, Meer weergeven Disfunction in the LRP2-mediated endocytic trafficking and endocytic capacity in the proximal tubule can result in low molecular weight proteinuria, which is a hallmark of many diseases. Mutations in the LRP2 gene are associated with Meer weergeven • Longoni M, Kantarci S, Donnai D, Pober BR (August 2008). "Donnai-Barrow Syndrome". In Adam MP, Mirzaa GM, Pagon RA, … Meer weergeven
ClC-5 does not affect megalin expression and function in the thyroid
Web1 apr. 2002 · Functions of cubilin and megalin The multiligand binding properties of both megalin and cubilin indicate a SCAVENGER RECEPTOR function, which mediates … WebMegalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors … robotforex12
Angiotensin II type 2 receptor activation preserves megalin in the ...
WebMegalin is active in the development and function of many parts of the body, including the brain and spinal cord (central nervous system), eyes, ears, lungs, intestine, reproductive … Web11 jul. 2014 · Megalin plays a particular key role in the proximal tubular uptake of glomerular-filtered albumin and other low-molecular-weight-proteins. Consistent with this function, megalin knockout mice develop low-molecular-weight proteinuria and albuminuria [ … Web30 mrt. 2004 · Dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of … robotframework airtest