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Jcog9511

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Webundertook a randomised phase 3 trial9 (JCOG9511) comparing irinotecan plus cisplatin with etoposide plus cisplatin in patients with extensive-stage SCLC. Response and overall survival were signiﬁ cantly better for patients treated with irinotecan than those treated with etoposide. The result prompted us to explore the use of irinotecan Webbenefit in JCOG9511. The combination chemotherapy with CPT-11þ VP-16 also shows promising results (Karato et al, 1993; Masuda et al, 1998). It is quite reasonable to investigate the three-

Combination treatment options for small-cell lung cancer

WebDownload scientific diagram Phase III Study of CPT-11/CDD vs VP-16/CDDP in SCLC (JCOG9511). from publication: Progress in treatment of small-cell lung cancer: Role of CPT-11 Small-cell lung ... Web13 dic 2013 · In contrast, the dose intensity of irinotecan (60 mg/m 2, Days 1, 8 and 15, every 4 weeks) was 45 mg/m 2 /week in JCOG9511. However, the omission of Day 15 irinotecan occurred in 50% of the courses in JCOG9511 . finding gold in electronics

Results of recent Japanese clinical trials in lung cancer

WebView the manual for the Canon PIXMA G4511 here, for free. This manual comes under the category Printers and has been rated by 16 people with an average of a 8.8. This manual is available in the following languages: English. Do you have a question about the Canon PIXMA G4511 or do you need help? [email protected] 1 Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-sayama, Osaka 589-8511, Japan 2 Department of Thoracic Oncology, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan finding gold in gippsland vic

Frontiers Cisplatin and Irinotecan as First-Line Chemotherapy for ...

Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 ... - Springer

Web3 beds, 1.5 baths, 1054 sq. ft. condo located at 8911G N 95th St, Milwaukee, WI 53224. View sales history, tax history, home value estimates, and overhead views. APN 0340607000. Web3 nov 2012 · In the JCOG9511 study , grade 3 to 4 diarrhea occurred in 16.0 % of patients treated with cisplatin plus CPT, whereas there was 8.0 % in the present study. Two patients who developed grade 3 diarrhea were switched to the cisplatin plus etoposide regimen and were able to receive a total of 4 cycles of first-line chemotherapy. finding gold in english riversWebThe results of JCOG9511 have recently been reported; and demonstrated that treatment with irinotecan/cisplatin significantly improved patient survival in extensive-stage small-cell lung cancer over standard etoposide/cisplatin, with less myelosuppression. finding gold in indiana

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Jcog9511

Lung Cancer Highlights The Oncologist Oxford Academic

Web肺癌 JCOG9511. Irinotecan plus cisplatin compared with etoposide plus cisplatin for small cell lung cancer: a randomized clinical trial（JCOG9511試験） Noda K, Nishiwaki Y, Kawahara M, et al. N Engl J Med. 2002; 346(2):85-91. Web1 gen 2014 · The doses of cisplatin were the same as in the previous JCOG trial (JCOG9511) in extensive-stage SCLC. 9 If the leucocyte count decreased to less than 3000 leucocytes per μL or the platelet count fell below 10 5 platelets per μL on the first day of etoposide plus cisplatin or irinotecan plus cisplatin, chemotherapy was withheld until the …

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Web25 mag 2024 · A phase III study showed the superiority of IP to EP in pts with extensive stage SCLC (JCOG9511). Methods: Pts with completely resected HGNEC were randomized in a 1:1 ratio to receive either etoposide (100 mg/m 2 , days 1-3)/cisplatin (80 mg/m 2 , day 1) or irinotecan (60 mg/m 2 , days 1, 8, 15)/cisplatin (60 mg/m 2 , day 1), using the … Web1 mag 2002 · In the past decade, the quality of Japanese clinical studies has improved tremendously. The results of JCOG9511 have recently been reported; and demonstrated that treatment with irinotecan/cisplatin significantly improved patient survival in extensive-stage small-cell lung cancer over standard etoposide/cisplatin, with less myelosuppression.

Web20 ago 2015 · A comparative analysis of response rates and toxicities between the IP arms of JCOG9511 and SWOG S0124 suggests that pharmacogenomic factors may account for differences in the efficacy and toxicities seen in the two trials. 7 In the IP arms, the incidence of grade 3–4 neutropenia was 65% in the JCOG 9511 trial and 34% in the SWOG S0124 … WebJCOG9511 (phaseIII) 進展型小細胞肺癌（ED-SCLC）に対する塩酸イリノテカン＋シスプラチンとエトポシド＋シスプラチンの第Ⅲ相無作為化比較試験. 研究グループ. ：. 肺がん内科グループ. 研究代表者. ：. 西條長宏. 国立がんセンター中央病院.

Web10 gen 2002 · Background: Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. In a phase 2 study of irinotecan plus cisplatin in patients with extensive small-cell lung cancer, there was a high response rate and a promising median survival time. Web(JCOG9511). Proc Annu Meet Am Soc Clin Oncol. 2000;19:1887. Abstract. Compared to cisplatin plus etoposide, the current standard approach for extensive-stage small-cell lung cancer,cisplatin and CPT-11 showed a significant improve-ment in median survival (420 days vs 300 days). If these data are con-firmed, cisplatin and CPT-11 may

WebJCOG9511 (phaseIII) 進展型小細胞肺癌（ED-SCLC）に対する塩酸イリノテカン＋シスプラチンとエトポシド＋シスプラチンの第Ⅲ相無作為化比較試験研究グループ

Web10 ago 2024 · JCOG previously reported the results of a randomized phase III trial (JCOG9511). They found that irinotecan, an inhibitor of the nuclear enzyme topoisomerase I, could improve OS and PFS when combined with platinum. Nevertheless, a series of studies conducted in America and Europe failed to confirm these positive results … finding gold in idahohttp://www.jcog.jp/document/9511.htm finding gold in iowaWeb1 ago 2000 · Randomized Phase III Study of Irinotecan (CPT-11) and Cisplatin Versus Etoposide and Cisplatin in Extensive- Disease Small-Cell Lung Cancer: Japan Clinical Oncology Group Study (JCOG9511). K Noda, Y Nishiwaki, M Kawahara, S Negoro, T Sugiura, A Yokoyama, M Fukuoka, K Mori, K Watanabe, T Tamura, N Saijo, K … finding gold in marylandWebBackground This phase I study evaluated the safety and tolerability, pharmacokinetics and pharmacodynamics, immunogenicity, and antitumor activity of pembrolizumab in Japanese patients with advanced solid tumors. Methods Following an initial dose and a 28-day rest (cycle 1), pembrolizumab was admini … finding gold in louisianaWebJCOG9511 trial (2002) showed longer overall survival in Japanese patients treated with cisplatin–irinotecan than in patients treated with cisplatin–etoposide (12·8 months . vs. 9·4 months, p=0·002). 3. However, oncologists in Europe and in the USA did not accept cisplatin–irinotecan as a standard regimen because the results of JCOG9511 ... finding gold in illinoisWebHouse located at N95W24511 County Rd Q, Colgate, WI 53017. View sales history, tax history, home value estimates, and overhead views. APN LSBT0154999. finding gold in michiganWebIrinotecan and cisplatin versus etoposide and cisplatin in small-cell lung cancer: JCOG 9511. Clin Lung Cancer. 2000 Aug;2 (1):23-4. finding gold in maine