FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and … See more Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. See more Yu & Fellows et al. (2024) demonstrated that FOXO3a activation in vascular smooth muscle cells induces prominent apoptosis and extracellular matrix breakdown in vitro and exacerbates atherosclerosis and vascular remodelling in vivo. Also, these processes were at … See more Deregulation of FOXO3a is involved in tumorigenesis, for example translocation of this gene with the MLL gene is associated with … See more In a meta-analysis of 78,308 individuals of European descent, a particular single nucleotide polymorphism (SNP) (rs2490272) in an … See more Gopinath et al. (2014) demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling pathway (an essential regulator of quiescence in adult stem cells See more Genetic variation in FOXO3 has been shown to be associated with healthspan and longevity in humans. It is found in most centenarians across a variety of ethnic groups around the world. The homologous genes daf-16 in the nematode C. elegans and dFOXO in the See more • FOX proteins • Daf-16 See more WebPotential Forkhead Box O 3a as Prognostic Biomarker in Prostate Cancer. A Putriyuni, MZ Oktora, N Nurwiyeni, T Tofrizal. 1st International Conference on Health Sciences and Biotechnology (ICHB 2024 ...

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WebNov 13, 2009 · Forkhead box class O 3a (FOXO3a) is an important direct target of the phosphatidylinositol 3-kinase (PI3K)/protein B(Akt) pathway, mediating signal … WebFOXF2 A gene on chromosome 6p25.3 that encodes a member of the forkhead family of transcription factors, which is expressed in lung and placenta and may play a role in … meeting my dad for the first time ever

Forkhead box protein O1: functional diversity - DDDT DDDT

WebApr 8, 2024 · As a member of the forkhead class of DNA-binding proteins, FOXA2 was verified to regulate the transcription of carnitine palmitoyltransferase 2 (CPT2) , ciliary neurotrophic factor , receptor-interacting protein kinase 3 , and multidrug resistance protein 2 . We demonstrated that knockdown of FOXA2 reduced IRAK1 transcription. WebNov 16, 2024 · Therefore, we purposed to investigate the effects of ROS-detoxifying molecules including Silent Information Regulator T1 (SIRT1) and Forkhead Box O 1 … WebJun 10, 2015 · Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-α-mediated neuronal damage: implications for human immunodeficiency virus... meeting my online best friend roblox