http://www.zen-bioscience.com/prod_view.aspx?IsActiveTarget=True&TypeId=163&Id=429948&FId=t3:163:3 WebPrexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC 50 =8 nM) and RSK1 (IC 50 =9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis.
Maternal diabetes induces senescence and neural tube defects …
WebOct 14, 2024 · Small molecular weight inhibitors: ALK inhibitors: Lymphoma : BTK inhibitors: Lymphoma [57,89,100,102,103,104,105,106,107] CDK inhibitors: Lymphoma [105,106] Osteosarcoma ... BETis synergise with ATR and Chk1 inhibitors in MYC-dependent lymphoma cells and are associated with increased DSBs and the induction of … WebMolecular Biology • PCR & qPCR • RT-PCR ... CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC 50 of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC 50 of 29 nM. HY-18174E Prexasertib dimesylate. Inhibitor 98.28% project windows surface to tv
CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response …
WebChk1 (G-4) is a mouse monoclonal antibody raised against amino acids 1-476 representing full length Chk1 of human origin. PRODUCT Each vial contains 200 µg IgG 2a kappa … WebChk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression (1). Activation of Chk1 involves phosphorylation at Ser317 … WebThe Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal … la joie bakery cafe