WebFeb 13, 2024 · Rather, Aim2 deficiency contributed to an increased production of CXCL16 by B cells, which could suppress S1PR1 and CD62L in CD8 + T cells. This study describes a potentially novel function of Aim2 that regulates CD8 + T cell infiltration and retention within chronically inflamed solid organ tissue. WebAbsent in melanoma 2 (AIM2) is an interferon-inducible protein containing an amino-terminal pyrin domain and carboxy-terminal HIN-200 domain that functions in innate immunity and …
AIM2 deficiency in B cells ameliorates systemic lupus
WebAIM2 is a cytosolic innate immune receptor which recognizes double-stranded DNA (dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of dsDNA leads to the assembly of a large multiprotein oligomeric complex … WebNov 15, 2024 · AIM2 was a signature gene in a BCR-activated subset after HCT, and AIM2 transcripts were significantly increased in a pre-germinal center (GC) B cell subset in … growing weeders into leaders
The complex role of AIM2 in autoimmune diseases and …
WebApr 11, 2024 · The mRNA (B) and protein (C) expression levels of AIM2 in MOCK group and AIM2-OE group of HCCLM3 and SMMC-7721 cell line were verified. To further study the essential role of AIM2 in the functional regulation of HCC cells, we investigated whether cell proliferation, migration and invasion capacities, and apoptosis assays were altered … WebInterferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.. AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin. AIM2-like receptor (ALR) family was founded on AIM2 … WebJun 29, 2024 · In this regard, we were not able to detect circulating AIM2 positive B cells, most likely because of the pathology considered. Thus, we consider that AIM2 activation … growing weed at home appliances